the Pharmacist
Rorta Junior
everything is a poison. The doesage alone makes it not one
Posts: 103
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Post by the Pharmacist on Jul 15, 2003 0:19:37 GMT -5
Alright, this thread is going to be about the use of different foods and drugs that increase(potentiate) the effects of drugs. Opiates are in my opinion the most easily potentiated drugs commonly available. Perscription drugs such as phenergan(promethazine) which is an antihistamine with anticholinergic properties potentiate opiates(especially codiene) by allowing more of the codiene to be converted into morphine by the liver. Other drugs which can potentiate opiates are as follows. Benadryl....benadryl contains diphenhydramine HCL, which is a derivative of scopolamine. Diphenhydramine is another antihistamine that is also used as an antinauseant. Diphenhydramine also helps fight nausea and opiate itch in addition to increasing the effects. Grapefruit juice is a potentiator to both benzodiazopenes and hydrocodone/oxycodone. It works by inhibiting the P450 cytochrome liver enzyme. (Note that codiene, heroin, and opium all rely on the P450 enzyme to convert them into morphine, which is the only natural opiate that is capable of bonding with the Mu opioid receptors.) Tagamet works in the same way as grapefruit juice. Be sure to take the opiate about thirty to forty five minutes prior to taking the tagamet, as the antacid properties will slow the absoption rate of the opiates to a crawl, and prevent many of the desired effects. Quinine and quinidine accentuate the euphoric sensations of opiates, but only potentiate codiene by aiding in the conversion of it to morphine. Well thats all I feel like typing up right now, but here is a link to more opiate potentiator information. www.coldwaterworld.com/potentiators.html
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the Pharmacist
Rorta Junior
everything is a poison. The doesage alone makes it not one
Posts: 103
|
Post by the Pharmacist on Jul 15, 2003 4:26:09 GMT -5
Hello again. In this second post, I will outline some information about using monoamine oxidase inhibitors(MAOI's) to potentiate tryptamine drugs.
Perhaps the most important thing to learn about MAOI's is their course of action, and the drug and food interactions and their consequences.
Monoamine oxidase metabolizes norephinephrine, dopamine and serotonin. Monoamine oxidase inhibitors inhibit the metabolization of these neurotransmiters, which causes a spike in the amounts of these neurotransmiters. This helps corrects some chemical imbalances, and is why MAOI's are sometimes prescribed as anti depressants, even though they are risky in some situations.
Tryamine is an amino acid that normaly would be metabolized by MAO in the gut. Taking an MAOI causes a buildup of dietary tryamine levels in the blood. This is dangerous because of tryamine's effect on norephinephrine and hypertension crisis follows. Blood pressure levels skyrocket to well over 180+. Pulse increases to 100 bpm or more. In the best case scenario, a extremely painful headache is the only consequence. In the worst case, your body could throw a clot, you could stroke out, and end up a vegetable. Ca blocker drugs are used to prevent these hypertension crisises.
Tryamine is found in some meats, cheeses, wines, and other food products that are aged. Symptathomimetic drugs such as amphetamines, MDMA, OTC cold remedies that contain drugs like ephidrine, and detromethorphan also lead to these hypertensive episodes.
In my next post, I will delve into the interactions between MAOI's and tryptamines. I hope some of you have learned something about MAOI's, and maybe have developed a respect for what they are capable of.
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the Pharmacist
Rorta Junior
everything is a poison. The doesage alone makes it not one
Posts: 103
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Post by the Pharmacist on Jul 15, 2003 6:38:42 GMT -5
Now it's time to walk through the doors backwards my friends, and explore the interactions between N,N-DMT, 5MEO-DMT, psilocybin, psilocin, and naturaly occuring MAOI's. The reason I am focusing specificaly on natural MAOI's is because MAOI's have two different classifications, Irreversable, and reversible MAOI's. Irreversible MAOI's bind permanently to the MAO enzymes, and cause inhibition that last for 1 to 2 weeks. This situation could potentaly be hazardous, because of the risk of tryamine buildup. We will focus on reversable MAOI's, particularly the beta-carbolines harmala and harmine. These work in much the same way as irreverible MAOI's, but their duration of action is limited to about 24 hours. Harmaline and harmine are the two most widely used MAOI's for recreational and spiritual drug use in the entire world for this reason.
Monoamine oxidase is the primary inactivation pathway of most tryptamines. This is why MAOI's can be used to potentiate the effects of tryptamines, and also make DMT, and 5MEO-DMT orally active. While these two tryptamines are psychoactive on their own when smoked, or insnuffilated, the MAO enzymes block it's action in the gut.
The natives of the Amazon river basin discovered the link between these two types of chemicals hundreds, if not thousands of years ago, and learned to combine the Banisteriopsis cappi vine(which contains harmine, harmaline, and other beta-carbolines) with DMT containing plants. They made this into an orally active brew called ayahausca.
Syrian rue seeds(Peganum harmala) is the most concentrated natural source of harmine, and harmaline. About 3 percent of their weight is comprised of these alkaloids. One gram of syrian rue seed is usually sufficient to inhibit MAO enough to activate and potentiate either of the DMT tryptamines for oral use.
On a side note, I am sure some of you have either heard about or seen psilocybin mushrooms that are covered in choclate for sale in your areas. The reason behind this seeming madness is that chocolate is a very weak MAOI. Chocolate is not strong enough to activate DMT orally however. It does potentiate the psilocin and psilocybin though.
Harmine, and harmala are hallucinogenic on their own in doses starting around 300 mgs. They have little or no emotional, or "psychadelic" effects, but do produce strong visual hallucinations. To add extra punch to your oral DMT explorations, I would suggest taking at least the 300 mgs if not 500 mgs.
I hope you have stuck with me through these two long posts. If you have, and are cautious, you can now experience the spell of ayahuasca if you are brave enough, or you can just potentiate your psilocybe mushies. Have fun and be careful.
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the Pharmacist
Rorta Junior
everything is a poison. The doesage alone makes it not one
Posts: 103
|
Post by the Pharmacist on Jul 16, 2003 1:01:48 GMT -5
Damn, I just posted a long drawn out explaination of how sodium bicarbonate(baking powder) causes potentiation of dextroamphetamine...It didn't take.
Oh well here goes the condensed version.
Sodium bicarbonate causes better absorption of amphetamine into the bloodstream. This in turn causes potentiation. The baking powder alkalinizes the gastrointestinal tract, and this facilitates the process. According to rxlist.com, urinary alkalinizing agents cause a slowing of excretement of amphetamine, leading to a longer half life.
1 to 2 teaspoons of baking powder should be sufficient to potentiate detroamphetamine. I am not sure if methamphetamine is affected the same way.
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